Conclusions: This study showed that long-term 5α-RIs therapy but not tamsulosin in men with BPH is associated with continued worsening of ED, which does not resolve with continuing treatment, contrary to previous claims. Most importantly, it appears that 5α-RIs therapy but not tamsulosin results in a reduction of T levels and increased AMS score as […]
Tag Archives: Proscar
Safety concerns regarding 5α reductase inhibitors for the treatment of androgenetic alopecia.
Recent postmarketing reports and a US Food and Drug Administration analysis have documented uncommon persistent sexual and nonsexual side-effects in a subset of younger men who have taken finasteride 1 mg for androgenic alopecia. While the mechanisms of the sexual side-effects in humans is incompletely understood, one study found lower cerebrospinal fluid concentrations of dihydrotestosterone, […]
2023 PFS Foundation Annual Address
Aug. 4, 2023 Dear Friends: Finasteride was first approved by the US Food and Drug Administration in April 1993. But let’s put that aside for a moment. Let’s instead step back just a dozen years. In April 2011, I was driving down the Garden State Parkway, on my way from New York City, where I […]
France Orders ‘Red-Box’ Warning—and QR Code Linking to PFS-Awareness Dossier—Slapped on all Finasteride 1 mg Products by April
Dec. 4, 2022 Dear Friends: French PFS awareness is going high-tech. ANSM, the Gallic nation’s drug-regulatory authority (DRA), last week unveiled plans to add a so-called “red-box” warning—that includes a QR code—on all finasteride 1 mg products in 2023. Intended to “reinforce information on adverse effects” of Propecia and generics, the warning reads: This medication […]
Why Is This Hair-loss Drug Still on the Market? German Public TV Asks of Finasteride
Reporter calls disclosure by nation’s drug-regulatory agency ‘shocking and unbelievable’ Nov. 2, 2022 Dear Friends: Anti-finasteride sentiment continues to run rife on Teutonic TV. Dürfen Die Das? (Can They Do That?), a newsmagazine show on the German public-broadcasting network NDR, last week debuted a 17-minute film titled Finasteride: Why Is This Hair-loss Drug Still on […]
Allopregnanolone Counteracts Finasteride-induced Alterations in Gut Microbiota, According to New University of Milano Research
Study marks first-ever demonstration of a successful PFS therapy in an animal model Oct. 29, 2022 Dear Friends: The neurosteroid allopregnanolone (ALLO) has proved effective in counteracting some of the finasteride-induced alterations in gut microbiota, according to new research at the University of Milano (UniMi). Titled Gut Inflammation Induced by Finasteride Withdrawal: Therapeutic Effect of […]
PFS Is ‘Clearly a Problem,’ ‘Warrants Intervention’ and Is ‘Inappropriate to Dismiss,’ Says New USC Research
Israeli pharmacovigilance expert, meanwhile, calls for ‘revolution’ in ADR reporting after local family of PFS suicide case files suit against Merck Sept. 26, 2022 Dear Friends: If you’ve ever Googled “post-finasteride syndrome,” chances are you’ve earned a place in the annals of medicine. Researchers at the University of Southern California’s Keck School of Medicine (KSM) […]
First-ever Suicidality ADRs Added to US Propecia Product Label, per FDA Mandate
But Patient Product Information not revised to include the potentially lethal adverse events Aug. 29, 2022 Dear Friends: Organon & Co., the Merck & Co. spinoff that now owns Propecia (finasteride 1 mg), has added a new adverse drug reaction (ADR) to the hair-loss remedy’s label: suicidality. Earlier this month, Organon updated the Adverse Reactions […]
Family of Second Baylor-study Patient Who Took His Own Life Goes Public via New York Post Report
Steve Kenney (1972-2014) was a beloved detective protecting the people of DeKalb County, GA Aug. 13, 2022 Dear Friends: In Mohit Khera’s groundbreaking PFS research, published in June 2020, the Director for Andrology Research at Baylor College of Medicine wrote, “Two patients (8%) in the 5ARI arm committed suicide during or after the study period.” […]
2022 PFS Foundation Annual Address
Aug. 4, 2022 Dear Friends: This month marks a full decade that we’ve been in the business of facilitating PFS research, generating awareness of the condition, providing support to patients suffering from the condition, and lobbying for stricter regulation so that fewer unsuspecting men develop the condition. Now, if at any time between August 2012 […]