Recent findings in rat models confirmed that altered epigenetic processes, consisting in abnormal DNA methyltransferase protein levels and increased global DNA methylation levels, are linked to anxiety- and depression-like behaviour. Our finding of high levels of methylated SRD5A2 in CNS cells of a normotensive hydrocephalus individual, displaying an epigenetic status at odds with all other […]
Tag Archives: persistent sexual dysfunction
Sexual dysfunction in men taking systemic dermatologic medication: A systematic review.
Although there is some evidence against sexual dysfunction occurring in patients taking 5 mg and 10 mg of finasteride, most studies describe relatively common adverse effects of decreased libido, impotence, and ejaculation disorders… We identified 5 studies that did not support the increased rates of sexual dysfunction in men taking 1 mg finasteride for androgenic […]
Gene-Expression Study in the Penile Skin Tissue of PFS Patients Finds Significant Differences in the Expression of 3,764 Genes
July 14, 2021 Dear Friends: The first study to consider and demonstrate gene expression differences as a potential etiology of the sexual dysfunction experienced by PFS patients has been published by a research team at Baylor College of Medicine (BCM). In all, the PFS patients had 1,446 significantly over-expressed (upregulated) and 2,318 significantly under-expressed (downregulated) […]
Unsealed Documents from Propecia Litigation Now Housed on PFS Foundation Website
June 29, 2021 Dear Friends: The PFS Foundation has launched a new section of its website to house documents from the US Propecia litigation unsealed by court order earlier this year. Part A of our Propecia Litigation Library (Paper Trail), contains 479 pages of such documents, along with 125 pages of related content, including Merck’s […]
In Addition to Blocking 5α-R, Finasteride Inhibits Adrenaline Production, Possibly Inducing Sexual and Psychological Side Effects, New Research Suggests
Finasteride patients face a 51% greater risk of suicidal ideation or suicidal behavior than the general population, separate study demonstrates April 13, 2021 Dear Friends: Phase V of the PFS Foundation-sponsored research at the University of Milano (UniMi) has found that finasteride, a 5-alpha reductase (5α-R) inhibitor, also inhibits phenylethanolamine N-methyltransferase (PNMT), an enzyme found […]
PFS Foundation Files Supplements to FDA Citizen Petition Seeking Finasteride’s Removal from the Market
US District Court, meanwhile, orders all sealed documents in Propecia litigation to be unsealed February 1, 2021 Dear Friends: The PFS Foundation has filed supplements to its FDA Citizen Petition requesting that the agency “immediately require withdrawal of marketing approval for Propecia…because the risk of serious injury from the drug outweighs its limited benefits.” The […]
New Hindi-Language Site Adds 615 Million Potential Readers to the PFS Awareness Movement
January 20, 2021 Dear Friends: The nation that gave us such wise figures as Mahatma Gandhi, Srinivasa Ramanujan and Anandibai Joshi just got a bit wiser. With respect to PFS, that is. Now, speakers of the world’s third most popular language can read all about post-finasteride syndrome (aka “पोस्ट-फ़ाइस्टरसाइड सिंड्रोम”) in their native tongue. To […]
France’s FDA Equivalent Issues Information Point and Fact Sheet on Finasteride Adverse Effects
December 19, 2019 Dear Friends: France’s FDA-equivalent agency last week issued an Information Point and fact sheet for men currently taking finasteride for hair loss, or for those considering taking the drug for hair loss. “Developed in conjunction with concerned patient associations and health professionals, this fact sheet aims to reinforce patient information on the […]
Young Men Using Finasteride for Alopecia May Be More Suicide-Prone than the General Population, Says New Pharmacovigilance Research
Nov. 12, 2020 Dear Friends: Men 45 years old and younger who use finasteride for hair loss are three times more likely to experience suicidal ideation, plan their suicide or attempt suicide, according to a new pharmacovigilance investigation. Risk of such suicidality was 63 percent higher than among men using other alopecia medications, including minoxidil […]
Gut Microbiota Population is Altered in PFS Patients, New Research Demonstrates
Sept. 28, 2020 Dear Friends: Phase IV of the PFS Foundation-sponsored research at the University of Milano (UniMi), designed to investigate the presence of altered gut microbiota in PFS patients, has successfully demonstrated the presence of altered gut microbiota in PFS patients. Titled Alterations of gut microbiota composition in post-finasteride patients: a pilot study, the […]