Data here obtained by RNA sequencing showed that chronic treatment (i.e., for 20 days) with finasteride affects the expression of hypothalamic and hippocampal rat genes. As we reported, the most affected brain area is the hypothalamus, with 15 genes downregulated and 171 genes upregulated. Among the downregulated genes, we will here discuss those that, based […]
Tag Archives: neuroendocrine disorder
Post-Finasteride Syndrome And Post-SSRI Sexual Dysfunction: Two Clinical Conditions Apparently Distant, But Very Close
Post-finasteride syndrome and post-SSRI sexual dysfunction, are two poorly explored clinical conditions in which men treated for androgenetic alopecia with finasteride or for depression with SSRI antidepressants show persistent side effects despite drug suspension (e.g., sexual dysfunction, psychological complaints, sleep disorders). Because of some similarities in the symptoms, common pathological mechanisms are proposed here. Indeed, […]
Comparative effects of finasteride and minoxidil on the male reproductive organs: A systematic review of in vitro and in vivo evidence
In our systematic review, we have assessed and compared for the first time the impact of two important medicaments, finasteride and minoxidil, both used to treat alopecia, on male reproduction. Two reproductive organs of adult murine models, testis and epididymis, in addition to testis/epididymis-related cells, were focused on this investigation. We can conclude that finasteride […]
The Post-Finasteride Syndrome: Possible Etiological Mechanisms and Symptoms
[I]t is utmost important to identify individuals with a previous history of depression, sexual dysfunction or infertility who may be more susceptible for the various side effects. The risks should than be discussed with the patient and weighed out against the benefits of the use of 5ARIs as mentioned in the introduction. Men under the […]
Exploring Rat Corpus Cavernosum Alterations Induced by Finasteride Treatment and Withdrawal
Data here reported indicate that the subchronic treatment with finasteride is able to directly affect the enzyme 5α-R type II in the rat corpus cavernosum and consequently the conversion of T into DHT. Indeed, we reported a decrease in its protein expression, associated with rise in the levels of its substrate and a decrease in […]