Exploring Rat Corpus Cavernosum Alterations Induced by Finasteride Treatment and Withdrawal

Data here reported indicate that the subchronic treatment with finasteride is able to directly affect the enzyme 5α-R type II in the rat corpus cavernosum and consequently the conversion of T into DHT. Indeed, we reported a decrease in its protein expression, associated with rise in the levels of its substrate and a decrease in the levels of its first product, DHT. Therefore, our observations indicated that a subchronic treatment with this drug, in addition to what we previously reported in plasma, also locally decreases the levels of DHT.

Melcangi RC, Diviccaro S, Herian M, Cioffi L, Audano M, Mitro N, Caruso D, Giatti S: Aug. 24, 2023 https://doi.org/10.1111/andr.13515 [Andrology]