In our systematic review, we have assessed and compared for the first time the impact of two important medicaments, finasteride and minoxidil, both used to treat alopecia, on male reproduction. Two reproductive organs of adult murine models, testis and epididymis, in addition to testis/epididymis-related cells, were focused on this investigation. We can conclude that finasteride and minoxidil harm the testis and testis-derivate cell cultures. Furthermore, our outcomes revealed that finasteride can damage the epididymis in murine models. It is apparent that both medications act as hormone disruptors, cause oxidative stress, and directly or indirectly affect the BTB in the testicular tissue, thus preventing it from functioning normally.
Santana F, Lozi A, Gonçalves R, Da Silva J, Da Matta A. Comparative effects of finasteride and minoxidil on the male reproductive organs: Nov. 1, 2023. https://doi.org/10.1016/j.taap.2023.116710. [Toxicology and Applied Pharmacology]