The Post-Finasteride Syndrome Foundation’s primary mission is to fund research on the characterization, underlying biologic mechanisms and treatments of post-finasteride syndrome (PFS). Other goals include generating public awareness of PFS and providing support for patients suffering from the condition.
Adverse drug reaction reports worldwide
PFS research studies published
Known suicides worldwide
Doctors & researchers speaking out
Nations warning of PFS
Using finasteride for hair loss is like shooting at sparrows with cannons.
Using finasteride for hair loss is like shooting at sparrows with cannons. The drug.…blocks not only the super hormone but also other hormones that affect thinking and psyche, mood and emotions. Discontinuation of the drug should actually make the hormones work again.…but apparently, something breaks down in some men, in the prostate, in the brain, in the whole organism.
—I Didn’t Want to Go Bald. A Pill the Doctor Gave Me Destroyed My Life (English translation): Die Zeit, Feb. 22, 2018
We wouldn’t recommend that any man take [finasteride], especially not young men.
We are certainly very cautious, because we see the side effects. We wouldn’t recommend that any man take [finasteride], especially not young men. The longer they take it, the greater the risk of experiencing persistent side effects, including after they’ve stopped.
—Do Anti-Baldness Remedies Make You Impotent? Puls, SRF-TV, May 7, 2018
For the first time, we demonstrate a tissue-specific methylation pattern of SRD5A2 promoter in PFS patients.
For the first time, we demonstrate a tissue-specific methylation pattern of SRD5A2 promoter in PFS patients [which] could represent an important mechanism of neuroactive steroid levels and behavioral disturbances previously described in PFS… The SRD5A2 promoter was more frequently methylated in the CSF of PFS patients compared to controls (56.3 versus 7.7%).
—Altered methylation pattern of the SRD5A2 gene in cerebrospinal fluid of post-finasteride patients: a pilot study: Endocrine Connections, July, 2019
FDA is concerned that use of finasteride by pediatric patients may pose long-term safety risks.
Finasteride inhibits Type II 5(alpha)-reductase, which metabolizes testosterone to the potent androgen 5(alpha)-dihydrotestosterone. FDA is concerned that use of finasteride by pediatric patients may pose long-term safety risks regarding growth, development and sexual function.
—FDA response to Merck & Co.’s citizen petition requesting that finasteride be added to the List of Approved Drugs for Which Additional Pediatric Information May Produce Health Benefits in the Pediatric Population: May 2000
February 25, 2019 Dear Friends: PFS awareness is fanning out across Europe faster than a leaky dyke. The latest nation to take up our charge is the Netherlands, via its second-largest newspaper, De Volkskrant, which boasts a daily circulation of more than 250,000. In a 2,600-word story that ran last week, reporter Irene de Zwaan […]
February 10, 2019 Dear Friends: Vive la France! This time we call your attention to a PFS report last week on 66 Minutes, which models itself after the iconic American news magazine 60 Minutes and boasts a Sunday-evening audience of two million viewers. The 14-minute segment, titled Is This Hair-loss Drug Dangerous? (English-subtitled version here), […]
February 2, 2019 Dear Friends: Encore! Prompted by an increasing number of adverse drug-reaction reports to finasteride, France’s FDA-equivalent agency yesterday issued a letter to 100,000 health professionals reminding them that patients treated with the drug are at risk for developing psychiatric disorders and persistent sexual disorders. The Agence Nationale de Sécurité du Médicament et […]
February 1, 2019 Dear Friends: Looks like Switzerland’s not so neutral after all. At least when it comes to finasteride. In a SonntagsZeitung story headlined Finasteride was once considered a miracle cure for hair loss. But soon libido disorders and other serious side effects were discovered. Now it’s going to court (English translation here ), […]
January 25, 2019 Dear Friends: France is at it again. Doing the right thing, that is. Earlier this week, Le Monde—the nation’s second-largest newspaper, with a daily circulation of more than 300,000 copies—ran a story headlined When Fighting Hair Loss, Watch out for Finasteride. (English translation here.) The 1,170-word report, by Pascale Santi, begins: “Romain […]