The Post-Finasteride Syndrome Foundation is dedicated to helping fund research on the characterization, underlying biologic mechanisms and treatments of the post-finasteride syndrome (PFS). A secondary goal is to help increase public awareness of PFS.

Often life-altering, PFS is characterized by devastating sexual, neurological, and physical side effects that persist in men who have taken the 5-alpha reductase type II enzyme inhibitor finasteride.

Finasteride is prescribed for the treatment of hair loss under the brand name Propecia (and generics) and for the treatment of enlarged prostate under the brand name Proscar (and generics).


Post Finasteride Syndrome

Among the most common finasteride side effects being reported to health agencies are loss of libido, erectile dysfunction, orgasm disorders, depression, Peyronie’s disease and abnormal breast enlargement. Unfortunately for some men, such side effects can persist for months or even years after stopping the drug. [more...]


Post Finasteride Syndrome Research

The PFS Foundation’s primary objective is to help establish medical consensus and acceptance of PFS by promoting scientific and clinical research. Research initiatives focus on uncovering underlying biologic mechanisms for the syndrome and its persistent side effects at a molecular level. [more...]


Post Finasteride Syndrome Publications

As media awareness and scientific interest in PFS continues to grow, the PFS Foundation will serve as a central resource for published research on the condition. We aim to facilitate collaborative efforts amongst health care professionals and leading scientists worldwide.  [more...]

PFS in the News

Prof. A.M. Traish, Boston University


Our research definitely concludes that PFS is real. For a subset of these men, the damage persists — maybe forever — even after they go off the drug. We don’t fully understand why, but it is as if something shuts off biologically, and stays that way.

A.M. Traish, Prof. of Biochemistry and Urology, Boston University School of Medicine

Irwin Goldstein, MD
We are becoming more and more aware of persistent sexual health problems occurring as a result of the use of 5-alpha reductase inhibitors, finasteride, and dutasteride, in a subset of patients. What is even more alarming is that in addition to persistent sexual issues, there are persistent central cognitive issues and concerns of persistent depression.

Irwin Goldstein, MD, Editor-in-Chief of the Journal of Sexual Medicine