In this pharmacovigilance case-noncase study, significant RORs of suicidality and psychological adverse events were associated with finasteride use in patients younger than 45 years who used finasteride for alopecia. The sensitivity analyses suggest that these disproportional signals of adverse events may be due to stimulated reporting and/or younger patients being more vulnerable to finasteride’s adverse […]
Tag Archives: suicide
Alterations of gut microbiota composition in post-finasteride patients: a pilot study
Sexual dysfunction, psychological and cognitive complaints, muscular problems, and physical alterations symptoms were reported in more than half of the PFS patients at the moment of sample collection. The quality sequence check revealed a low library depth for two fecal samples. Therefore, the gut microbiota analyses were conducted on 21 patients. The α-diversity was significantly […]
Repeated finasteride administration induces depression-like behavior in adult male rats
This study provides the evidence that an animal model of finasteride-induced depression is feasible to investigate the cellular and molecular mechanisms, and the pharmacology underlying the neuropsychiatric effects of finasteride. Further, these results provide insights into the potential involvement of neurosteroids in depression and will lead to the development of novel therapeutics for its treatment. […]
Allopregnanolone, the Neuromodulator Turned Therapeutic Agent: Thank You, Next?
Pharmacological treatments, including finasteride and oral contraceptives, that inhibit 5α-RI, which results in a blood and brain allopregnanolone decrease also affect subunit expression of GABAA receptor and are associated with mood symptoms and suicide and are part of post-finasteride syndrome. Post-finasteride syndrome, in addition to depression, anxiety and cognitive deficits also induces sexually-related side effects, […]
Macular Abnormalities Associated With 5α-Reductase Inhibitor
Among 31 male patients with foveal cavitation, 5-ARI was used for 10 of 14 patients (71.4%) with macular abnormalities of unknown origin and for 2 of 17 patients (11.8%) with macular abnormalities of well-known specific origin… Optical coherence tomography imaging showed a disease spectrum ranging from tiny foveal cavitation to an impending macular hole. Of […]
An evaluation of the federal adverse events reporting system data on adverse effects of 5‑alpha reductase inhibitors
Post-finasteride syndrome (PFS) has been described as physical, neurological, or psychiatric side effects which persist for three or more months after discontinuing the medication, affecting approximately 900,000–1.5 million men. In 2015, the National Institute of Health (NIH) added PFS to their list of genetic and rare disease… Analysis of FAERS data suggests [adverse events] of […]
Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia
While the sexual side effects of 5ARIs are well known, there may be persistent genitourinary, physical, psycho-cognitive, anti-androgenic and penile vascular changes after 5ARI discontinuation. Use of 5ARIs for treatment of AGA may lead to persistent sexual, genitourinary, physical, psycho-cognitive, and anti-androgenic sequelae even after cessation of 5ARI therapy… Two subjects (8%) committed suicide during […]
Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm
Here we advance the concept that blockade of the 5α-R enzymatic activities by such irreversible inhibitors results in a state of new form of androgen deficiency, independent of circulating T levels. This new form of androgen deficiency has not been recognized before, simply, it is thought that as long as T levels are in the […]
Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women
[F]inasteride is associated with common adverse health effects in women with long-term treatment for androgenetic alopecia such as; irregular menstrual cycle, aromatase disorder, high cholesterol, heavy menstrual bleeding and induced DNA damage…Finally, the study recommended that finasteride should not be administrated as treatment for androgenetic alopecia in women. Albasher G, Bin-Jumah M, Alfarraj S, et […]
Post-finasteride syndrome: a surmountable challenge for clinicians
It is not surprising that almost all studies published to date do report increased sexual adverse effects. However, even when such sexual adverse events were reported, many argued that the numbers of subjects afflicted are small and propagated the falsehood that the adverse effects do resolve with continued treatment. This is unfortunately a willful blindness […]