Treatment of male rats with finasteride, an inhibitor of 5alpha-reductase enzyme, induces long-lasting effects on depressive-like behavior, hippocampal neurogenesis, neuroinflammation and gut microbiota composition.

Our findings indicate that finasteride treatment causes several alterations in the hippocampus that are detected at the end of the treatment… coincide with the apparition of depressive-like behavior, suggesting that long term effects of finasteride treatment on neurogenesis and neuroinflammation may participate in the enduring effects of the drug on depressive-like behavior, which are detected […]

2023 PFS Foundation Annual Address

Aug. 4, 2023 Dear Friends: Finasteride was first approved by the US Food and Drug Administration in April 1993. But let’s put that aside for a moment. Let’s instead step back just a dozen years. In April 2011, I was driving down the Garden State Parkway, on my way from New York City, where I […]