Anxiety-, and depression-like behavior following short-term finasteride administration is associated with impaired synaptic plasticity and cognitive behavior in male rats

Interestingly, we observed that finasteride impairs hippocampal-dependent spatial memory but not prefrontal cortex-dependent recognition memory… This study suggests that finasteride administration induced anxiety-, and depression-like behavior and impaired hippocampal dependent learning and synaptic plasticity and provides insight that neurosteroids play an important role in mood and cognition.

Sasibhushana RB, Shankaranarayana Rao BS, Srikumar BN: April 28, 2024 [Journal of Psychiatric Research]