Common Pathways Between PFS and Post-SSRI Sexual Dysfunction Could Be Useful in Designing Therapeutic Strategies for Both, Says New University of Milano Study

April 30, 2018

Dear Friends:

Roberto Cosimo Melcangi, Ph.D., head of the Neuroendocrinology Unit in the Department of Pharmacological and Biomolecular Sciences at the University of Milano, has published a new paper in the current issue of Endocrine: International Journal of Basic and Clinical Endocrinology.

Titled Post-finasteride syndrome and post-SSRI sexual dysfunction: two sides of the same coin?, the nine-page review “discusses the knowledge accumulated so far on the pathological phenotype of post-finasteride syndrome (PFS) and of post-SSRI sexual dysfunction (PSSD).”

“Sexual dysfunction is a feature shared by PFS and PSSD. This common aspect could be casual or rather be determined by common mechanisms that, once detected, could be useful to understand the pathophysiology and to possibly design therapeutic strategies for these conditions,” writes Prof. Melcangi, whose research team on this project includes Silvia Giatti, Silvia Diviccarom, and Giancarlo Panzica.

“In particular…neuroactive steroids, serotonin and dopamine are variably interconnected with PSSD and PFS… The finding that both PFS and PSSD, and consequently the persistent sexual dysfunction observed, occurred only in a limited number of patients may suggest possible epigenetic mechanisms,” he adds.

Please note that this review is separate from Prof. Melcangi’s current study, designed to examine epigenetic changes in PFS patients. For details on that research, which we announced in January, please access our Foundation News page.

If you’d like to help advance medical research on PFS, please visit our Donate page soon and give generously.

Thank you.