PFS, though rare, significantly impacts quality of life, with unclear etiology and no definitive treatment. Risk-benefit assessment and informed patient consent are essential before prescription… The persistence of symptoms after drug discontinuation is one of the most concerning aspects of this syndrome, raising troubling questions about the potentially permanent impact of this medication on an individual’s quality of life. Despite extensive studies and a well-known side-effect profile, reports of adverse effects persisting for at least three months after finasteride use have increased, especially among younger users.
—An (Ir)reversible Affection of the Sexual Sphere: A Case Report: Journal of Psychosexual Health, February 2026