The persistent symptoms reported by men after treatment of BPH or AGA with 5α-reductase inhibitors have been increasingly studied over the past decade. However, many of the studies investigated PFS using surveys of patients seeking treatment for PFS or from PFS-specific online forums, exposing the results to potential selection and recall bias. Further, there is a paucity of randomized clinical trials to more definitively outline the relationship between 5α-reductase inhibitors and persistent adverse effects. Additionally, much of the research centers on the adverse effects after finasteride use leaving the occurrence of PFS after dutasteride use inadequately explored. Treatment options for the symptoms of PFS have also yet to be clearly outlined or investigated.
Than, J. K., Rodriguez, K., & Khera, M. (2018). Post-finasteride Syndrome: A Review of Current Literature. Current Sexual Health Reports, 10(3), 152–157. doi:10.1007/s11930-018-0163-4 [Curr Sex Health Rep]