Macular Abnormalities Associated With 5α-Reductase Inhibitor

Among 31 male patients with foveal cavitation, 5-ARI was used for 10 of 14 patients (71.4%) with macular abnormalities of unknown origin and for 2 of 17 patients (11.8%) with macular abnormalities of well-known specific origin… Optical coherence tomography imaging showed a disease spectrum ranging from tiny foveal cavitation to an impending macular hole. Of the total male patients, 80.0% (8 of 10) had no symptoms… The findings suggest that macular abnormalities associated with 5-ARI are characterized by cystoid abnormalities and foveal cavitation in male patients, which may progress to outer foveal defect and macular hole.

Yong KS, Geun WL, Se WK, et al. JAMA Ophthalmol. 2020;138(7):732-739. doi:10.1001/jamaophthalmol.2020.1279 [JAMA Ophthalmology]