An evaluation of the federal adverse events reporting system data on adverse effects of 5‑alpha reductase inhibitors

Post-finasteride syndrome (PFS) has been described as physical, neurological, or psychiatric side effects which persist for three or more months after discontinuing the medication, affecting approximately 900,000–1.5 million men. In 2015, the National Institute of Health (NIH) added PFS to their list of genetic and rare disease… Analysis of FAERS data suggests [adverse events] of 5ARIs are dose-independent with greater likelihood of occurrence in younger patients, particularly in sexual and mental domains.

Harrell, M.B., Ho, K., Te, A.E. et al. World J Urol (2020). [World Journal of Urology]